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LIPOSOMA provides liposomal and other lipid based products as a CMO and branded label provider, offering platform technology for a wide range of human health products. LIPOSOMA operates in a variety of industries, ranging from immunological research to vitamin supplements and medical nutrition. It is LIPOSOMA’s mission to be a world leading lipid nanoparticle based company, guaranteed by its commitment to scientific excellence.

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1.1 Product Description 1.2 Products List 1.2.1 CLODRONATE LIPOSOMES 1.2.2 CLODRONATE LIPOSOMES & CONTROL LIPOSOMES (PBS) 1.2.3 CLODRONATE LIPOSOMES & FLUORESCENT DII LIPOSOMES 1.2.4 CONTROL LIPOSOMES (PBS) 1.2.5 FLUORESCENT DII LIPOSOMES

Products

Product Description

The phospholipid bilayers are composed of phosphatidylcholine and cholesterol. All liposomal formulations are suspended in sterile phosphate buffered saline (PBS):

• 10 mM Na2HPO4
• 10 mM NaH2PO4
• 140 mM NaCl

All our liposomes are slightly negatively charged and will therefore not clog together. The liposomes in the suspension are not sized, meaning that it contains smaller and larger liposomes as well (up to 3 micron). On average, the size of the liposomes are 1.7 micron.

Clodronate liposomes: Artificial spheres consisting of concentric phospholipid bilayers encapsulating an aqueous PBS (phosphate buffered saline) solution containing clodronate. Liposomes are particles, sized at a max. of 3 micron. They form a suspension in PBS and will tend to precipitate upon storage, forming a pellet on the bottom of the tube or flask. The suspension should be shaken before administration to laboratory animals in order to recover the homogeneous suspension. The concentration of clodronate in the suspension is ca. 5 mg/ml.

Control liposomes (PBS): Control liposomes do not contain clodronate. Containing PBS only, they can be used for control experiments, in order to find out whether the effects observed after injection of clodronate liposomes are due to macrophage depletion exclusively.

Fluorescent DiI Liposomes: Control liposomes, labeled with the fluorochrome DiI can be used to investigate whether liposomes injected via a particular administration route are able to reach the macrophages to be studied. They can also show other macrophage populations reached by the liposomes injected via this route.

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Products List

CLODRONATE LIPOSOMES
Product	SKU	Quantity
	C-005	5 ml (5ml Clodronate Liposomes)
	C-010	10 ml (10ml Clodronate Liposomes)
	C-015	15 ml (15ml Clodronate Liposomes)
	C-020	20 ml (20ml Clodronate Liposomes)
	C-030	30 ml (30ml Clodronate Liposomes)
	C-040	40 ml (40ml Clodronate Liposomes)
	C-050	50 ml (50ml Clodronate Liposomes)
	C-100	100 ml (100ml Clodronate Liposomes)
CLODRONATE LIPOSOMES & CONTROL LIPOSOMES (PBS)
Product	SKU	Quantity
	CP-005-005	5 ml (5 ml Clodronate Liposomes + 5 ml Control Liposomes (PBS))
	CP-010-010	10 ml (10 ml Clodronate Liposomes + 10 ml Control Liposomes (PBS))
	CP-015-015	15 ml (15 ml Clodronate Liposomes + 15 ml Control Liposomes (PBS))
	CP-020-020	20 ml (20 ml Clodronate Liposomes + 20 ml Control Liposomes (PBS))
	CP-030-030	30 ml (30 ml Clodronate Liposomes + 30 ml Control Liposomes (PBS))
	CP-040-040	40 ml (40 ml Clodronate Liposomes + 40 ml Control Liposomes (PBS))
	CP-050-050	50 ml (50 ml Clodronate Liposomes + 50 ml Control Liposomes (PBS))
	CP-100-100	100 ml (100 ml Clodronate Liposomes + 100 ml Control Liposomes (PBS))
CLODRONATE LIPOSOMES & FLUORESCENT DII LIPOSOMES
Product	SKU	Quantity
	CI-005-005	5 ml (5 ml Clodronate Liposomes + 5 ml Fluorescent DiI liposomes)
	CI-010-010	10 ml (10 ml Clodronate Liposomes + 10 ml Fluorescent DiI liposomes)
	CI-015-015	15 ml (15 ml Clodronate Liposomes + 15 ml Fluorescent DiI liposomes)
	CI-020-020	20 ml (20 ml Clodronate Liposomes + 20 ml Fluorescent DiI liposomes)
	CI-030-030	30 ml (30 ml Clodronate Liposomes + 30 ml Fluorescent DiI liposomes)
	CI-040-040	40 ml (40 ml Clodronate Liposomes + 40 ml Fluorescent DiI liposomes)
	CI-050-050	50 ml (50 ml Clodronate Liposomes + 50 ml Fluorescent DiI liposomes)
	CI-100-100	100 ml (100 ml Clodronate Liposomes + 100 ml Fluorescent DiI liposomes)
CONTROL LIPOSOMES (PBS)
Product	SKU	Quantity
	P-005	5 ml (5 ml Control Liposomes (PBS))
	P-010	10 ml (10 ml Control Liposomes (PBS))
	P-015	15 ml (15 ml Control Liposomes (PBS))
	P-020	20 ml (20 ml Control Liposomes (PBS))
	P-030	30 ml (30 ml Control Liposomes (PBS))
	P-040	40 ml (40 ml Control Liposomes (PBS))
	P-050	50 ml (50 ml Control Liposomes (PBS))
	P-100	100 ml (100 ml Control Liposomes (PBS))
FLUORESCENT DII LIPOSOMES
Product	SKU	Quantity
	I-005	5 ml (5 ml Fluorescent DiI liposomes)
	I-010	10 ml (10 ml Fluorescent DiI liposomes)
	I-015	15 ml (15 ml Fluorescent DiI liposomes)
	I-020	20 ml (20 ml Fluorescent DiI liposomes)
	I-030	30 ml (30 ml Fluorescent DiI liposomes)
	I-040	40 ml (40 ml Fluorescent DiI liposomes)
	I-050	50 ml (50 ml Fluorescent DiI liposomes)
	I-100	100 ml (100 ml Fluorescent DiI liposomes)

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