PRIMACYT – Skin discs & dermatomed skin Order Information|Tokyo Future Style, Inc.

PRIMACYT – Skin discs & dermatomed skin Order Information

We develop and provide cell culture systems for the prediction of toxic and long-term effects of agents on the human body.　Worldwide support of biomedical and cell biology research as well as industrial communities.We accompany projects to fully understand the metabolism, toxicity and functional effects of the liver system.

Our Strengths

PRIMACYT is one of the pioneers in the development of advanced in vitro model systems. We are a leading company in the field of research of human and animal hepatocytes.
In 2008, we have received the Research Prize of the German Ministry of Nutrition, Agriculture and Consumer Protection for the “Development and validation of a serum-free, standardized and re-usable human hepatocyte culture system for the analysis of food, drugs and chemicals”.
PRIMACYT is approved by the European Commission as an EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) since 2013 and serves as a member of the laboratory network responsible for the method validation.
Main products, liver-derived and skin-derived products, are cryopreserved at the first passage stage, and the product information below clearly states the viability, recovery rate, suitable plates for culture, and test results for 3D culture.

Skin tissues Order Information

Overview

PRIMACYT offers dermatomed and full thickness skin discs from human donors. These ex vivo skin explants serve as valuable model systems and tools for drug discovery, safety evaluation of chemicals, pesticides and cosmetic active ingredients. The human skin discs are used for applications like

Characterisation of topically applied pharmaceuticals (OECD TG 428)
Safety assessment of biocides, agrochemicals (EU 528/2012)
Safety evaluation of cosmetic ingredients
Classification of substance based medical devices (EU 2017/745)

Literature

D. Marques-da-Silva, M. Franco, C. Violante, R. Lagoa: Permeation studies of chlorpyrifos through skin and synthetic membranes to improve the in vitro dermal absorption assay of lipophilic compounds with ethanolic receptors, 2025,
https://doi.org/10.1016/j.yrtph.2025.105931

P. Shah, J. Elkins, S.-Y. Lam, and J. P. Skelly: Determination of in vitro drug release from hydrocortisone creams. Int. J. Pharmaceutics, 1989, 53:53-59,
DOI: 10.1016/0378-5173(8I9)90361-X

S.-F. Ng, J. J. Rouse, F. D. Sanderson, V. Meidan, and G. M. Eccleston: Validation of a Static Franz Diffusion Cell System for In Vitro Permeation Studies. AAPS PharmSciTech, 2010, 11:1432-1441,
DOI: 10.1208/s12249-010-9522-9

OECD GUIDELINE FOR THE TESTING OF CHEMICALS Skin Absorption: in vitro Method (OECD TG 428).

EFSA Guidance Dermal Absorption

EU Regulation No. 528/2012 Biocides

EU Regulation No. 2017/745 Medical devices

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Tokyo Future Style, Inc.
info@tokyofuturestyle.com
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