PRIMACYT – Cryopreserved Equine (Horse) Hepatocytes|Tokyo Future Style, Inc.

PRIMACYT – Cryopreserved Equine (Horse) Hepatocytes

We develop and provide cell culture systems for the prediction of toxic and long-term effects of agents on the human body.　Worldwide support of biomedical and cell biology research as well as industrial communities.We accompany projects to fully understand the metabolism, toxicity and functional effects of the liver system.

Our Strengths

PRIMACYT is one of the pioneers in the development of advanced in vitro model systems. We are a leading company in the field of research of human and animal hepatocytes.
In 2008, we have received the Research Prize of the German Ministry of Nutrition, Agriculture and Consumer Protection for the “Development and validation of a serum-free, standardized and re-usable human hepatocyte culture system for the analysis of food, drugs and chemicals”.
PRIMACYT is approved by the European Commission as an EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) since 2013 and serves as a member of the laboratory network responsible for the method validation.
Main products, liver-derived and skin-derived products, are cryopreserved at the first passage stage, and the product information below clearly states the viability, recovery rate, suitable plates for culture, and test results for 3D culture.

Equine (Horse) Hepatocytes Order Information

Overview

Animal health plays an important role not only for the welfare of pets and domestic farm animals but also for animals used in food production. For the development of veterinary drugs we offer liver cells from a variety of species including dog, horse, sheep, goat, pig, poultry and fish.

A number of these animals also play an important role in environmental risk assessment of herbicides and fungicides used in crop protection. Isolated hepatocytes from ruminants, poultry and fish have increasingly become an important research tool in metabolism and bioaccumulation studies. Cost-saving test methods using hepatocyte cultures as alternatives to animal experiments will reduce the number of animal experiments and are currently introduced into OECD test guidelines.

Literature

Berlin S.et al.: Pharmacokinetics and Pulmonary Distribution of Clarithromycin and Rifampicin after Concomitant and Sonsecutive Administartion in Foals, 2016, 1089-1099

Berlin S. et al.: Instestinal and hepatic contribution to the pharmacokinetic interaction between gamithromycin and rifampicin after single-dose and multiple-dose administration in healthy foals, 2018, 525-531

Andrea Rasche, Felix Lehmann, Nora Goldmann, Michael Nagele, Andres Moreira-Sotoa, Daniel Nobach, Ianei de Oliveira Carneiroa, Nikolaus Osterrieder, Alex D. Greenwood, Eike Steinmann, Alexander N. Lukashev, Gerhard Schuler, Dieter Glebe, Jan Felix Drexler, and the Equid HBV Consortium: A hepatitis B virus causes chronic infections in equids worldwide. PNAS 2021 Vol. 118 No. 13, https://doi.org/10.1073/pnas.2013982118

Khaled A. Shibany, Sabine Tötemeyer, Stefanie L. Pratt & Stuart W. Paine: Equine hepatocytes: isolation, cryopreservation and applications to in vitro drug metabolism studies, Pharma Res Per, 4 (5), 2016, e00268, doi: 10.1002/prp2.268

With supporting information https://www.pnas.org/lookup/suppl/doi:10.1073/pnas.2013982118/-/DCSupplemental.

Product List

Product Code	Lot	Sex	Inventory (vials)	Viability (%)	Recovery (Viable cells/vial)	plateable 24well	plateable 96well	3D culture	CYP1A1/1A2 induction Xfold
EHCP	EH150225-3	female	21 in stock	73.0 +/- 11.3	> 4 Mio.	yes	no	not tested	–
EHCP	250206-1	female	10 in stock	93.7	> 4 Mio.	yes	yes	no	–
EHCP	250206	female	80 in stock	86.9 +/- 3.3	> 6 Mio.	yes	no	no	no

※EHCP – Equine (horse) hepatocytes cryopreserved plateable

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Tokyo Future Style, Inc.
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