PRIMACYT – Fibroblasts|Tokyo Future Style, Inc.

PRIMACYT – Fibroblasts

We develop and provide cell culture systems for the prediction of toxic and long-term effects of agents on the human body.　Worldwide support of biomedical and cell biology research as well as industrial communities.We accompany projects to fully understand the metabolism, toxicity and functional effects of the liver system.

Our Strengths

PRIMACYT is one of the pioneers in the development of advanced in vitro model systems. We are a leading company in the field of research of human and animal hepatocytes.
In 2008, we have received the Research Prize of the German Ministry of Nutrition, Agriculture and Consumer Protection for the “Development and validation of a serum-free, standardized and re-usable human hepatocyte culture system for the analysis of food, drugs and chemicals”.
PRIMACYT is approved by the European Commission as an EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) since 2013 and serves as a member of the laboratory network responsible for the method validation.
Main products, liver-derived and skin-derived products, are cryopreserved at the first passage stage, and the product information below clearly states the viability, recovery rate, suitable plates for culture, and test results for 3D culture.

Human and Cynomolgus Fibroblasts

Overview

PRIMACYT offers skin cells from human and non-human primates. Dermal fibroblasts are obtained from human and Cynomolgus monkey ex vivo skin explants. These ex vivo skin explants and their cellular products serve as valuable model systems and tools for drug discovery and cosmetic development.

Literature

Dermal Fibroblasts – Cultured Human and Non-Human Primate Fibroblasts from PRIMACYT.

What are fibroblasts? Dermal fibroblasts are derived from mesenchymal stem cells. The function of fibroblasts is related to maintenance and tissue metabolism. Such fibroblasts are in activated state of metabolism. Fibroblasts provide the structural fibers and ground substance of connective tissue.

Compared to other fibroblast cell types, dermal fibroblast cells show only weak affinity to change into other cell types. Fibroblast proliferation can be stimulated by the presence of fibroblast growth factor (FGF).

Human Dermal Fibroblasts utilize their organelles to join separate cell layers. One of the fibroblast functions is the provision of the human protein molecules, including fibronectin and laminin, for the creation of the extracellular matrix (ECM).

Fibroblasts from Cynomolgus Monkey (alt. “Cynomolgus Macaque”) are fibroblasts for research purposes from primates because their dermal cells are very close to human fibroblasts.

Product Code	Lot	Sex	Inventory (vials)	Viability (%)	Recovery (Viable cells/vial)	Specification
NHDF-JF	059-131024	male	36 in stock	93	0.9 Mio.	Foreskin
NHDF-AD	045-130206	male	21 in stock	95	1.0 Mio.	Foreskin
NHDF-AD	049-120410	female	12 in stock	94	1.9 Mio.	Eyelid
NHDF-AD	050-120410	female	11 in stock	95	1.5 Mio.	Eyelid
NHDF-AD	051-120410	female	22 in stock	88	2.3 Mio.	Eyelid
NHDF-AD	053-120508	female	12 in stock	91	1.6 Mio.	Eyelid
NHDF-AD	054-120820a	female	19 in stock	89	0.6 Mio.	Breast
NHDF-AD	057-131026	female	45 in stock	95	0.9 Mio.	Eyelid
NHDF-JF	042-120903a	male	16 in stock	85	0.9 Mio.	Foreskin
NHDF-JF	042-120903b	male	17 in stock	84	1.1 Mio.	Foreskin
NHDF-JF	043-120918a	male	16 in stock	95	0.8 Mio.	Foreskin
NHDF-JF	043-120918b	male	15 in stock	96	0.9 Mio.	Foreskin
NHDF-JF	044-120918a	male	16 in stock	90	0.5 Mio.	Foreskin
NHDF-JF	044-120918b	male	15 in stock	96	0.9 Mio.	Foreskin
NHDF-JF	047-120213	male	14 in stock	89	2.3 Mio.	Foreskin
NCDF	062-190124	female	34 in stock	97	3.6 Mio.	Face
NCDF	063-B-190805	female	27 in stock	100	1.1 Mio.	Face
NCDF	067-3-190812	male	78 in stock	100	1.3 Mio.	Face

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NHDF-AD – Normal Human Dermal Fibroblasts, adult donor
NHDF-JF – Normal Human Dermal Fibroblasts, juvenile foreskin
NCDF – Normal Cynomolgus Dermal Fibroblasts

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Tokyo Future Style, Inc.
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