AMK（N1-acetyl-5-methoxykynuramine）
Compound AMK, anticipated to enhance long-term memory, is now available for applications ranging from research reagents to manufacturing
Manufactured by Fuji Molecular Planning Co., Ltd.
Distributed by Tokyo Future Style, Inc.
About Compound “AMK”
AMK (N1-acetyl-5-methoxykynuramine) is a metabolite of the pineal hormone melatonin, and may promote the formation of long-term memory, which is thought to improve memory loss and dementia associated with aging. Development of new drugs based on AMK will improve age-related memory disorders and the early stages of dementia.
The Role of AMK in Memory Function
Aging is associated with a decline in AMK (N1-acetyl-5-methoxykynuramine) levels in the hippocampus, which may contribute to age-related memory impairment. Transcriptomic analysis of hippocampal tissue from aged and young mice revealed a significant downregulation of gene clusters associated with long-term memory in the aged group.
The Role of AMK Administration in Long-Term Memory Formation
Administration of AMK induces phosphorylation of proteins critical for memory formation in the hippocampus. A single administration of AMK either before or after learning is sufficient to enhance long-term memory in mice. Furthermore, AMK treatment improves memory formation capacity even in aged mice.
→ References
Ref : J. Pineal Research, vol70, issue1, e12703, 2021.
The melatonin metabolite N1-acetyl-5-methoxykynuramine facilitates long-term object memory in young and aging mice
https://onlinelibrary.wiley.com/doi/10.1111/jpi.12703
Product：AMK
Compound：N-Acetyl-5-methoxykynuramine
| CAS No | 52450-39-2 |
| Purity,Molecular Formula / Molecular Weight | >98%, C12H16N2O3=236.27 |
| Volume | 10mg, 100mg, 500mg, 1g, 10g, 100g |
| Storage temperature | Frozen (-20℃) |
| Production ability | 1kg/month |
| Physical Properties | Insoluble in water, soluble in organic solvents |
Product：AMK·HCl
Compound：N-Acetyl-5-methoxykynuramine hydrochloride
| CAS No | 1215711-91-3 |
| Purity,Molecular Formula / Molecular Weight | >98%, C12H16N2O3・HCl =272.73 |
| Volume | 10mg, 100mg, 500mg, 1g, 10g, 100g |
| Storage temperature | Frozen (-20℃) |
| Production ability | 1kg/month |
| Physical Properties | Dissolves in buffer solutions |
Product：AFMK
Compound：N-Acetyl-5-methoxykynuramine
| CAS No | 52450-38-1 |
| Purity,Molecular Formula / Molecular Weight | >98%, C13H16N2O4 =264.28 |
| Volume | 10mg, 100mg, 500mg, 1g, 10g, 100g |
| Storage temperature | Room temperature (10-20℃) |
| Production ability | 1kg/month |
| Physical Properties | Insoluble in water, soluble in organic solvents |
Homologue
We offer a wide range of compounds with a kynuramine structure. Please feel free to contact us
Please contact us for any inquiries, questions, or information requests.
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