PIC hydrogel – Noviocell BV

About Noviocell
Noviocell BV is a highly innovative biotechnology company, headquartered in Oss, the Netherlands. It has the next generation of synthetic solution for 3D cell culturing, opening up the avenues for clinical applications like organ transplantation and precision medicine. Noviogel can make clinical applications possible.
(Noviocell’s website is here

About Noviogel
Noviogel is synthetic and leads therefore, to reproducible results, it is biocompatible and it can be used for regenerative medical purposes. The gel is thermo-reversible and as a consequence it much easier to retrieve your cells or tissue from the hydrogel. It has no auto fluorescence and no contamination with DNA or RNA of your matrix.
Noviogel is a polyisocyanopeptide (PIC) hydrogel which is a new class of advanced polymers. The polymer has a helix-like structure that is similar to the conformation of collagen abundantly present in the extracellular matrix (structure around cells). Noviogel combines the unique benefits of natural and synthetic biomaterials. It uniquely performs like other extracellular matrix proteins, while possessing the same characteristics as other commercial hydrogels. Noviogel creates a cellular microenvironment with the right mechanical cues to control cell expansion and differentiation.


Advantages of PIC hydrogel
●No batch to batch variation – because of synthetic origin
●Excellent cell growth and differentiation
●Represents biomechanical properties similar to natural matrices – same elasticity as collagen
●Easy to use – reversible thermosensitive:
•    no difficulties in cell or organoid isolation
•    no difficulties with downstream processing or imaging after culturing
●Biofunctionality –  by clicking (growth) factor of choice to the polymer



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