|ViroStat was founded in 1985 by Dr. Douglas McAllister to provide infectious disease antibody tools to researchers and manufacturers. These include the areas of virology, bacteriology and parasitology. The company offers more than 500 infectious disease reagents including their MONOTOPE™ monoclonal antibodies, OMNITOPE™ polyclonal antibodies and numerous recombinant antigens.|
New Product Information
Monoclonal Antibodies to Avian Influenza Viruses
The CDC reports that the H5N1 Bird Flu has been detected in several species of wildbirds as well as domestic poultry flocks. Sporadic infections with this virus have also been detected in mammals (fox, raccoon, skunks, mountain lions). One US case has been reported following exposure to infected birds, but no person-to-person transmission has occurred.
ViroStat’s monoclonal antibodies target the highly conserved nucleoprotein of the Influenza A virus. Thus these monoclonal antibody pairs detect many Flu A isolates found in human, avian, swine and equine sources. These include viruses of H1-H14 types and N1-N9 types. Immunoassays utilizing these antibody pairs are useful for detecting Flu A in humans as well as for surveillance of circulation in other animal species.
|1331||Influenza A – from A/Texas strain.||Mouse||100 µg||Datasheet|
|1341||Influenza A – specific for nucleoprotein.||Mouse||100 µg|
|1361||Influenza A – specific for nucleoprotein.||Mouse||100 µg|
|1371||Influenza A – specific for nucleoprotein.||Mouse||100 µg|
|1381||Influenza A – specific for nucleoprotein.||Mouse||100 µg|
|1385||Influenza A – specific for nucleoprotein.||Mouse||100 µg|
|1333||Influenza A – from A/Texas strain.||Mouse||100 µg|
|1343||Influenza A – specific for nucleoprotein.||Mouse||100 µg|
Canine Coronavirus Antibodies
Canine Coronavirus causes a highly contagious infection of the gastrointestinal tract of dogs. It does not infect humans as it is an Alphacoronavirus 1 and does not cause respiratory disease. It is spread via oral contact with fecal matter or contaminated food. Puppies are especially susceptible often resulting in severe diarrhea.
ViroStat has just released a number of monoclonal antibodies to the Canine Coronavirus. These new antibodies are specific to the nucleocapsid of the virus and do not cross react with other Canine viruses. These antibodies form pairs for the rapid detection of the virus by immunoassay.
|3881||Canine Coronavirus||Mouse||100 µg||Datasheet|
|3882||Canine Coronavirus||Mouse||100 µg|
|3883||Canine Coronavirus||Mouse||100 µg|
Rapid Detection of Gram Negative Bacteria
Gram negative bacteria can cause a number of disease conditions including urinary tract infections, food-borne infections, typhoid fever and sepsis. Many of these bacteria can be detected by culture. However this method is labor intensive and slow. Rapid diagnosis is crucial for correctly treating these infections quickly.
ViroStat has just released a pair of Monoclonal Antibodies that detect the LPS common to many of these bacteria including E. coli, Salmonellae and Shigella among others. These antibodies are useful tools for rapid, non-culture based immunoassays including ELISA and lateral flow to directly detect these bacteria.
|1054||Gram negative bacteria||Mouse||100 µg||Datasheet|
|1055||Gram negative bacteria||Mouse||100 µg|
Urine Testing for Infectious Diseases
There are a number of Infectious Diseases of humans that result in specific antigens being excreted into the urine during infection. Often these antigens are glycans/carbohydrates originating from bacterial/fungal LPS or cell wall polysaccharides.
Urine is an ideal specimen, as it is taken non-invasively in contrast to blood or tissue biopsy.
Examples of these infections include:
- ・Pneumonia (Streptococcus pneumoniae)
- ・Legionellosis (Legionella pneumophila)
- ・Tuberculosis (Mycobacterium species)
- ・Aspergillosis (Aspergillus species)
ViroStat offers Rabbit Monoclonal antibodies to the specific antigens of all of these Infectious disease agents. They function as detection pairs, or self-pair, for antigen detection assays. All are available for use as raw materials in IVD devices.
|0494||Streptococcus pneumoniae CWPS||Rabbit||100 µg||Datasheet|
|0495||Streptococcus pneumoniae CWPS||Rabbit||100 µg|
|0435||Group A Streptococcus||Rabbit||100 µg||Datasheet|
|1525||Group B Streptococcus||Rabbit||100 µg||Datasheet|
|6026||Legionella pneumophila serogroup 1||Rabbit||100 µg||Datasheet|
|5179||Mycobacteria LAM||Rabbit||100 µg||Datasheet|
|5180||Mycobacteria LAM||Rabbit||100 µg|
|5144||Aspergillus species||Rabbit||100 µg||Datasheet|
|5145||Aspergillus species||Rabbit||100 µg|
|5146||Aspergillus species||Rabbit||100 µg|
NEW Leptospira Monoclonal Antibodies
Leptospira are spiral shaped bacteria several of which are pathogenic causing the infection Leptospirosis. Animals including dogs and rodents can transmit infection to humans, usually through contact with infected urine. The Leptospira enter the blood stream and can lead to kidney failure or pulmonary bleeding. Recommended treatment is doxycycline.
Pathogenic Leptospira include species such as L. interrogans and L. kirschneri can be differentiated from non-pathogenic species by several markers. Chief among these markers are several outer membrane lipoproteins.
ViroStat has just released a set of new Monoclonal Antibodies to the lipoprotein, LipL41. This is an abundant surface lipoprotein found on pathogenic species of Leptospira. These new antibodies form pairs to detect this marker via ELISA. Thus they have the potential to serve in additional immunoassay detection applications.
|0411||outer membrane lipoprotein LipL41||Mouse||100 µg||Datasheet|
|0412||outer membrane lipoprotein LipL41||Mouse||100 µg|
|0413||outer membrane lipoprotein LipL41||Mouse||100 µg|
|0414||outer membrane lipoprotein LipL41||Mouse||100 µg|
NEW Cryptosporidium parvum Monoclonal Antibodies
Cryptosporidium parvum is a major worldwide cause of gastrointestinal diarrheal disease. This is due in great part to the environmental resilience of its infectious Oocyst stage. These cysts are resistant to the usual levels of chloride used to disinfect swimming pools and treated wastewater. They are also resistant to freezing and changes in pH. Infection occurs via the fecal-oral route when the cysts are ingested. During infection large quantities of new cysts are shed in the feces.
ViroStat has just released two new Rabbit Monoclonal Antibodies that are reactive with Oocysts of Cryptosporidium parvum. These MabyRabs™ are specific to a cell wall glyco-antigen of the cyst. They form a pair to detect low levels of cysts by ELISA. They also stain the cysts by immunofluorescence and have potential in other immunoassay detection methods.
|7641||cyst cell wall glyco-antigen||Rabbit||100 µg||Datasheet|
|7642||cyst cell wall glyco-antigen||Rabbit||100 µg|
Canine Distemper Virus New Monoclonal Antibodies
Canine Distemper Virus (CDV) infects numerous wild and domestic animal species including dogs, cats, wolves and coyotes. The symptoms of this infection are system-wide affecting the respiratory, gastrointestinal and nervous system.
This virus is related to the viruses that cause measles and mumps and is extremely contagious via aerosols and body fluids. Especially vulnerable are puppies and non-vaccinated adults.
ViroStat has released a new set of Monoclonal Antibodies specific to the nucleocapsid of this virus. Select antibody pairs can be used for the detection of this virus by immunoassay methods including IFA and ELISA.
Go to the ViroStat website (www.virostat-inc.com) to download the data sheet for these new antibodies.
|7515||nucleocapsid of CDV||Mouse||100 µg||Datasheet|
|7516||nucleocapsid of CDV||Mouse||100 µg|
|7517||nucleocapsid of CDV||Mouse||100 µg|
Antigen Detection of COVID-19 Variants
Variants of this virus have evolved due to mutations in the Spike protein. While most antigen detection tests target the nucleocapsid of the virus with the use of antibody pairs. The nucleocapsid is relatively conserved in comparison to the Spike protein.
However mutations also do occur in the nucleocapsid. If the antibody pair used for detection now fails to bind to this antigen because of a mutation then this could result in a false negative test result.
All of ViroStat’s COVID-19 monoclonal antibodies have been validated for their reactivity with the nucleocapsids of the most common variants currently circulating including: UK B.1.1.7, South Africa B.1.351 and Brazil P.1. Thus ensuring that the variants will be detected with these antibodies.
|3851||nucleoprotein of SARS & COVID-19||Mouse||100 µg||Datasheet1|
|3861||nucleoprotein of SARS & COVID-19||Mouse||100 µg|
|3862||nucleoprotein of SARS & COVID-19||Mouse||100 µg|
|3863||nucleoprotein of SARS & COVID-19||Mouse||100 µg|
|3864||nucleoprotein of SARS & COVID-19||Mouse||100 µg|
Detection of Gram Positive BacteriaThere are medical conditions where rapid detection of Gram Positive bacteria is critical. An example of this is sepsis where time is of the essence. Most Gram Positive bacteria possess a cell wall polymer of lipoteichoic acid (LTA). LTA can be shed from growing bacteria and is also present on the intact bacterium itself.
ViroStat has just released a new set of monoclonal antibodies to LTA. These antibody pairs can be used to detect both free LTA as well as cell wall LTA of intact bacteria.
These new antibodies detect the LTA of many Gram Positive bacteria including: Staph aureus, Staph epidermidis, Strep pneumoniae, Strep pyogenes, Bacillus cereus, Bacillus subtilis, Enterococcus faecalis and Listeria species.
These new antibody pairs represent powerful tools for assay development for bacterial detection.
|3801||lipoteichoic acid||Mouse||100 µg||Datasheet|
|3811||lipoteichoic acid||Mouse||100 µg|
|3802||lipoteichoic acid||Mouse||100 µg|
|3803||lipoteichoic acid||Mouse||100 µg|
|3804||lipoteichoic acid||Mouse||100 µg|
NEW Antibodies for COVID-19 Virus Detection
The nucleocapsid of COVID-19 virus is ideal for antigen detection for two major reasons:
1) It is produced abundantly in infected cells
2) it is a highly conserved protein and therefore not prone to mutation.
The cytoplasm of infected cells fills with the nucleocapsid antigen. These cells can be collected on a NP swab and added to a specimen buffer to lyse and release this antigen for detection by immunoassay.
ViroStat has developed and just released a set of new monoclonal antibodies to the nucleocapsid of the COVID-19 virus. These final 5 antibodies were selected from an initial group of 60 based upon highest binding affinity and best ELISA pairing for detection of native viral antigen. Datasheet
Astrovirus Monoclonal Antibodies from VirostatAstrovirus is a relatively newly discovered family of non-enveloped RNA viruses that cause gastroenteritis in animals and humans. Young children and the elderly are most susceptible due to underdeveloped or waning immune systems respectively. Symptoms include vomiting and diarrhea which can lead to dehydration. The virus can be detected in feces via PCR and immunoassay.
ViroStat has released a set of new Monoclonal Antibodies to Astrovirus. These antibodies are specific to the major capsid protein of the virus and form pairs for detecting this antigen. Datasheet
Please contact us for any inquiries, questions, or information requests.
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