ACROBiosystems – TIGIT Signaling Axis|Tokyo Future Style is a bio-tech trading company

TIGIT (T cell immunoreceptor with Ig and ITIM domains) is a newly discovered immune checkpoint expressed on T cells and Natural Killer cells (NK). TIGIT is an inhibitory receptor which modulates the immune activity by competing with activating receptor CD226 (also known as DNAM1) for ligand binding. This on and off switch of TIGIT&DNAM1 parallels that of CTLA4&CD28, which makes it a promising target for anti-tumor therapy.

The ligands for TIGIT and DNAM1 including CD155 (PVR), also to CD112 (PVRL2 or Nectin 2), and CD113 (PVRL3 or Nectin 3). The affinity between different ligands and receptors vary. The binding between TIGIT and CD155 is more robust than that between TIGIT and CD112 or CD113.

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ACROBiosystems carries a large collection of recombinant proteins from TIGIT signaling axis. In addition to the commonly used his and Fc tagged proteins, we also carry multiple pre-biotinylated proteins such as Biotinylated Human TIGIT, Avi Tag (Avitag™) (Cat. No. TIT-H82E5)， Biotinylated Human CD155/PVR Protein, Fc Tag, Avi Tag (Avitag™) (Cat. No. CD5-H82F6) and Biotinylated Human Nectin-2/CD112 Protein, Fc Tag, Avi Tag (Avitag™) (Cat. No. CD2-H82F8). Please find detailed information below:

Biotinylated Human TIGIT, His Tag ELISA

Immobilized Human CD155, Fc Tag (Cat. No. CD5-H5251) at 10μg/mL (100 μL/well) can bind Biotinylated Human TIGIT, His Tag (Cat. No. TIT-H82E5) with a linear range of 0.08-0.31 μg/mL (QC tested)

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